Gut Health, Cognitive Health, Metabolic Health, Anti-Aging

ButyraGen® is an innovative, next-generation prebiotic – it is a direct butyrate generator for gut health and beyond, generating consistent levels of butyrate directly in the colon. Butyrate is a key short-chain fatty acid (SCFA) postbiotic that has been shown to be a critical signaling molecule for improving gut health and for gut-related effects on other organs via the gut-brain axis. ButyraGen® has the unique ability to generate butyrate mostly independent of the state of the microbiome, delivering benefits to a wide variety of people. ButyraGen® delivers benefits as a stand-alone, low-dose prebiotic, or in combination with probiotics to further enhance the health benefits across multiple gut-organ axes.

ButyraGen® is part of an exclusive portfolio of proprietary ingredients and is a trademark of NutriScience Innovations, LLC .

Features & Benefits
  • Prebiotic butyrate generator for gut health and beyond
  • Works well as a stand-alone, or in combination with probiotics
  • Works across multiple gut-organ axes, delivering a wide range of health benefits
  • Very low odor – almost no smell
  • Patent pending
  • Dietary Supplements
  • Functional Foods & Beverages
  • Animal Health
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Mechanism of Action

The active ingredients in ButyraGen® are tributyrin, a butyrate generator, and partially hydrolyzed guar fiber, a short chain fatty acid generator. Tributyrin is broken down in the gut by enzymes to generate high levels of the postbiotic butyrate. Butyrate is then available in the lumen. Butyrate plays an important role in intestinal barrier function and gut health, while also modulating immune and inflammatory responses. Receptors for butyrate are present in most cells in the body. Butyrate is also critical for the effects of the gut system on other organs (e.g. gut-brain axis, gut-skin axis, etc.).

Scientific Studies

ButyraGen® has been evaluated in pre-clinical studies, with future studies planned. The following health benefits are supported:

  • Generates butyrate and other short chain fatty acids
  • Significantly lower gas production when compared to other prebiotics
  • Reduces oxidative stress
Formulating with ButyraGen®

ButyraGen® is an off-white – light brown free flowing powder with a slight odor. ButyraGen® is a prebiotic and direct butyrate generator which can be used by itself, or in combination with probiotics.


ButyraGen®  is safe for human consumption and is FDA GRAS. All excipients are GRAS.

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