Capsaicin compound that is naturally present in chili peppers, it is extracted from the Capsicum Annum L. and/or Capsicum Frutescence varieties. Capsaicin can stimulates the nerve endings in the skin; it is often used as a component in many topical formulations used to help alleviate pain. Capsaicin 95% is for topical applications.
Mechanism of Action
Capsaicin is a neuropeptide-active agent that affects the synthesis, storage, transport, and release of substance P, which is believed to be the principal chemical mediator of pain impulses from the peripheral nervous system to the central nervous system. https://www.uspharmacist.com/article/capsaicin-risks-and-benefits
Formulating with Capsaicin
Capsaicin can be incorporated into topical creams, lotions, ointments, gels, and films